Kinetics of Muscle Carnosine Decay after β-Alanine Supplementation: A 16-wk Washout Study
نویسندگان
چکیده
منابع مشابه
The effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout measured by H-MR spectroscopy
Introduction: Carnosine (ß-alanyl-L-histidine) is a cytoplasmic dipeptide found in high concentrations in skeletal muscle, particularly in type II muscle fibers. Chronic (~4 weeks) ß-alanine (BA) supplementation (~5g BA/day) has been shown to increase muscle carnosine contents by >50%, which can contribute ~15% towards total intracellular muscle buffering capacity. However, the optimal BA dosin...
متن کاملCarnosine loading and washout in human skeletal muscles.
Carnosine (beta-alanyl-L-histidine) is present in high concentrations in human skeletal muscles. The oral ingestion of beta-alanine, the rate-limiting precursor in carnosine synthesis, has been shown to elevate the muscle carnosine content both in trained and untrained humans. Little human data exist about the dynamics of the muscle carnosine content, its metabolic regulation, and its dependenc...
متن کاملRole of beta-alanine supplementation on muscle carnosine and exercise performance.
In this narrative review, we present and discuss the current knowledge available on carnosine and beta-alanine metabolism as well as the effects of beta-alanine supplementation on exercise performance. Intramuscular acidosis has been attributed to be one of the main causes of fatigue during intense exercise. Carnosine has been shown to play a significant role in muscle pH regulation. Carnosine ...
متن کاملMuscle carnosine loading by beta-alanine supplementation is more pronounced in trained vs. untrained muscles.
Carnosine occurs in high concentrations in human skeletal muscle and assists working capacity during high-intensity exercise. Chronic beta-alanine (BA) supplementation has consistently been shown to augment muscle carnosine concentration, but the effect of training on the carnosine loading efficiency is poorly understood. The aim of the present study was to compare muscle carnosine loading betw...
متن کاملMuscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training.
Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase. Recent studies have shown that the chronic oral ingestion of beta-alanine can substantially elevate (up to 80%) the carnosine content of human s...
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ژورنال
عنوان ژورنال: Medicine & Science in Sports & Exercise
سال: 2020
ISSN: 1530-0315,0195-9131
DOI: 10.1249/mss.0000000000002559